中国癌症防治杂志Issue(1)：35-38,4.DOI:10.3969/j.issn.1674-5671.2014.01.08
亚甲基四氢叶酸还原酶基因C677T多态性与肺腺癌化疗疗效的关系
Correlation of methylenetetrahydrofolate reductase (MTHFR)C677T polymorphism and chemotherapy efficacy in lung adenocarcinoma
摘要
Abstract
Objective To investigate a possible correlation between C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR)gene and chemotherapy efficacy in patients with pulmonary adenocarcinoma. Methods Peripheral blood samples from 92 p atients with pulmonary adenocarcinoma were collected before chemotherapy,and the C677T polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).We examined whether genotype correlated with whether the patients showed partial response(PR),stable disease(SD)or progressive disease(PD)following chemotherapy. Results Of the 92 patients,56 (60.9%) had wild-type genotype (CC),13(14.1%) were homozygous mutant(TT),and 23(25.0%) were heterozygous mutant(CT).Among the patients treated with pemetrexed/carpoplatin as first-line regimen,CC patients showed an overall response rate (ORR)of 35.7%,with 20 CC patients achieving PR;19,SD;and 17,PD.Among TT patients,ORR was 15.4%,with 2 patients achieving PR;7,SD;and 4,PD.Among CT patients,ORR was 0,with 13 achieving SD and 10,PD.ORR was significantly higher in CC patients than in TT or CT patients (P=0.001).In addition,CC patients showed significantly longer time to progression (6.2 months)than did TT or CT patients (4.7 months;P=0.023).Among the patients treated with gemcitabine/nedaplatin or docetaxel/nedaplatin as second-line regimen,2 CC patients showed PR;5,SD;and 10,PD.3 TT patients achieved SD;among CT patients, 1 achieved PR,2 SD and 7,PD.ORR was similar between CC and TT/CT patients (P=1.000). Conclusions Pemetrexed in combination with carboplatin may be associated with greater therapeutic efficacy and longer time to progression in CC patients than in TT/C T patients.However,genotype at the MTHFR C677T polymorphism does not appear to influence the therapeutic efficacy of gemcitabine/nedaplatin or docetaxel/nedaplatin.关键词
肺肿瘤/非小细胞肺癌/亚甲基四氢叶酸还原酶/基因多态性/化疗疗效Key words
Lung neoplasms/Non-small cell lung cancer/Methylenetetrahydrofolate reductase/Gene polymorphism/Chemotherapy分类
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董翠梅,康马飞,赵燕仪,林静,陶利英..亚甲基四氢叶酸还原酶基因C677T多态性与肺腺癌化疗疗效的关系[J].中国癌症防治杂志,2014,(1):35-38,4.基金项目
广西卫生厅自筹科研课题 （）
