中国医药科学Issue(18)：7-8,15,3.
295例宫颈病变患者HPV亚型多重感染与宫颈病变的关系
Correlation between human papillomavirus muti-infection and cervical disease in 295 patients
摘要
Abstract
Objective To study the correlation between multiple papillomavirus(HPV)infection and cervical disease. Methods Using HPV genotyping technology, HPV subtypes were detected in cervical smear or paraffin-embedded cervical tissues samples. Results The total HPV infection rate was 58.98%(174/295). The constituent ratio of varied severity of cervical diseases were significantly different from those only infected high risk or multiple HPV(include high and low risk HPV)group and only infected low risk group(x2=16.801,P < 0.05;x2=11.303,P < 0.05); There was no significant difference between multiple high risk (or multiple low risk) and only high risk (or only low risk) group(x2=7.325,P>0.05;x2=4.362, P>0.05),respectively, while a significant difference was observed in people with only high risk and low risk infected types(x2=16.369, P<0.05). Conclusion The risk of cervical cancer was raised in women infected with high risk HPV subtypes compared with low risk groups,while the severity of cervical diseases was not increased with infected multiple HPV subtypes.关键词
人乳头瘤病毒/基因芯片技术/宫颈癌Key words
Human papillomavirus(HPV)/Gene array technology/Cervical cancer分类
医药卫生引用本文复制引用
张元,钱小华,柴莉,阮思蓓,罗霞,唐明希..295例宫颈病变患者HPV亚型多重感染与宫颈病变的关系[J].中国医药科学,2013,(18):7-8,15,3.基金项目
泸州医学院博士启动基金（2011204）；四川省泸州市科技局科技计划项目（2013-S-47）。 （）
