中国医药科学Issue(18)：29-31,3.
不同麻醉药对小鼠缺氧耐受性的影响及机制研究
Study on effect of different anaesthetics on hypoxia tolerance and possible mechanisms in mice
摘要
Abstract
Objective To explore the hypoxia tolerance of mice induced by different anaesthetics (pelltobarbitalum, tribromoethanol, urethane, and chloral hydrate) and the possible mechanisms. Methods Mice were randomly divided into six groups according to the material injected into their abdominal cavity: physiological saline group, propranolol group, pelltobarbitalum group, tribromoethanol group, urethane group, and chloral hydrate group. After intraperitoneal injection, hypoxia tolerance time and oxygen consumption were measured using the hypoxia bottles and the heart rate was recorded by Medlab. The effects of different anaesthetics on the hypoxia tolerance of mouse were investigated and the relationship between hypoxia tolerance time, oxygen consumption rate and heart rate were explored. Results Pelltobarbitalum, tribromoethanol, urethane, and chloral hydrate all could significantly prolonged the survival time of mice (P < 0.05), especially tribromoethanol and chloral hydrate. At the same time, oxygen consumption rate of the mice was significantly decreased by the four anaesthetics (P < 0.05), especially by tribromoethanol and chloral hydrate. Beside the oxygen consumption rate, tribromoethanol and chloral hydrate also significantly reduce the heart rate of mice (P<0.05). Conclusion Hypoxia tolerance has relationship with oxygen consumption and heart rate. Our results suggested that pelltobarbitalum and urethane could improve the hypoxia tolerance in mice through decreased oxygen consumption rate, whereas tribromoethanol and chloral hydrate improve the hypoxia tolerance by decreased oxygen consumption rate and heart rate.关键词
麻醉药/缺氧耐受性/小鼠Key words
Anaesthetic/Hypoxia tolerance/Mouse分类
医药卫生引用本文复制引用
刘秋晨,刘立民,张驰,施春花,韩玲,杜晓秋,戴骏琪,谢可鸣,孙晓东,张克平..不同麻醉药对小鼠缺氧耐受性的影响及机制研究[J].中国医药科学,2013,(18):29-31,3.基金项目
江苏省高等教育教学改革研究项目（SG315935）。 （）
