中国医药科学Issue(19)：12-14,3.
罗哌卡因复合利多卡因切口浸润在异丙酚-瑞芬太尼全凭静脉麻醉下行乳腺癌改良根治术患者中的应用
The application of incision infiltration with ropivacaine mixed with lidocaine in patients receiving radical mastectomy under total intravenous anesthesia with propofol and remifentanil
摘要
Abstract
Objective To study the influences of incision infiltration with 0.25% ropivacaine mixed with 0.5%lidocaine on hemodynamic stability, intraoperative anesthetic requirements,recovery status, and on the effects of postoperative patient controlled analgesia(PCIA) with fentanyl in patients receiving radical mastectomy under total intravenous anesthesia with propofol and remifentanil. Methods Forty patients scheduled for radical mastectomy, were randomly divided into two groups:the infiltration group(n=20), patients received incision infiltration with 0.25%ropivacaine mixed with 0.5% lidocaine 5min before skin incision and the control group(n=20), patients received incision infiltration with normal saline instead. Anesthetic induction and maintenance were the same in the two groups. For both groups, hemodynamic changes and the total consumption of propofol and remifentanil during operation, Visual analog scale(VAS) scores at the time of 5min after extubation and sedation-agitation scale(SAS) scores during recovery stage were all recorded.The VAS scores 24h after operation, the total consumption of fentanyl and the number of keystrokes during the first 24h PCIA were also recorded. Results The peak values of MBP and HR measured at the time of skin incision and post- mammary space dissection, the VAS scores 5min after extubation, the SAS scores during recovery stage, the total consumption of fentanyl and the number of keystrokes during the first 24h PCIA were all significantly lower than those of the control group(P<0.01 or P<0.05). Conclusion Incision infiltration with 0.25%ropivacaine mixed with 0.5%lidocaine, which can be easily implemented during surgery, could stabilize hemodynamics, reduce anesthetic consumption, and alleviate postoperative pain in patients receiving radical mastectomy under total intravenous anesthesia with propofol and remifentanil.关键词
罗哌卡因/利多卡因/切口浸润麻醉/乳腺癌改良根治术/血流动力学/镇痛Key words
Ropivacaine/Lidocaine/Incision infiltration anesthesia/Radical mastectomy/Hemodynamics/Analgesia分类
医药卫生引用本文复制引用
张静,沈智文,李玉娟..罗哌卡因复合利多卡因切口浸润在异丙酚-瑞芬太尼全凭静脉麻醉下行乳腺癌改良根治术患者中的应用[J].中国医药科学,2013,(19):12-14,3.基金项目
广东省自然科学基金面上项目（S2011010004558）。 （）
