中国医药科学Issue(19)：30-32,35,4.
归肺理气方对痰热壅肺证慢性阻塞性肺疾病大鼠血清与肺组织MMP-9和TIMP-1的影响
EffectofGuifeiLiqiRecipeonMMP-9andTIMP-1inbloodserumand lungtissueofthephlegmobstructthelungsyndromesofCOPD rats
堵玉萍1
作者信息
- 1. 上海市中西医结合医院肺病科，上海200082
- 折叠
摘要
Abstract
Objective To observe effect of GuifeiLiqiRecipe on the expression of MMP-9 and TIM P-1 in blood serum and lung tissue of the "phlegm obstruct the lung" syndromes of COPD rats. Methods 61SD rats were randomly divided into seven groups (normal group, normal+traditional Chinese medicine in dose of middle group, traditional Chinese medicine in dose of low, middle, high group, prednisone group). The rat model of COPD was established by using the method of cigarette smoking combined with intratracheal injection of lipopolysaccharide (LPS). The content of MMP-9 and TIMP-1 in blood serum and lung tissue were detected. Results The content of MMP-9, TIMP-1 and MMP-9/TIMP-1 in blood serum and lung tissue of the model group increased significantly compared with those of the normal group (P < 0.05). The content of MMP-9 and MMP-9/TIMP-1 of the traditional Chinese medicine in dose of middle, high group and prednisone group decreased significantly compared with those of the model group (P < 0.05). Conclusion GuifeiLiqiRecipe can adjust the MMP-9/TIMP-1 imbalance on the phlegm obstruct the lung syndromes of COPD rats. It perhaps has partial effect on improving air duct remodeling of COPD.关键词
归肺理气/慢性阻塞性肺疾病/基质金属蛋白酶-9/基质金属蛋白酶组织抑制剂-1Key words
GuifeiLiqi/Chronic obstructive pulmonary disease/Matrix metalloproteinases-9/Tissue inhibitor of metalloproteinases-1分类
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堵玉萍..归肺理气方对痰热壅肺证慢性阻塞性肺疾病大鼠血清与肺组织MMP-9和TIMP-1的影响[J].中国医药科学,2013,(19):30-32,35,4.
