中国医药科学Issue(20)：27-28,32,3.
hOGG1基因多态性与胃癌遗传易感性的关系
Relationship between polymorphism in hOGG1 and XPD and genetic susceptibility to gastric cancer
于兆亚 1汤静2
作者信息
- 1. 河南大学淮河医院检验科，河南开封475000
- 2. 河南省医药学校，河南开封475000
- 折叠
摘要
Abstract
Objective To investigate the relationship between polymorphism in human 8-oxoguanine DNA glycosylase 1(hOGG1) and xeroderma pigmentosum group D (XPD) and genetic susceptibility to gastric cancer. Methods The peripheral blood samples of 98 cases of gastric cancer and 80 non-tumor volunteers(control group) in Zhengzhou and Kaifeng of Henan were collected, the peripheral DNA repair enzyme gene polymorphism in gastric cancer populations were detected by using polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP), and it's relationship with genetic susceptibility to cancer was analyzed. Results There were significant differences in genotypes frequency of hOGG1Ser326Cys and XPD Lys751Gln between gastric cancer group and control group (P < 0.05). Lys751Gln genotype had the 1.7 times inceased risk of developing gastric cancer (OR=1.706, 95%CI=0.341 ~ 2.462,P=0.002). The interactions between hOGG1Ser 326Cys polymorphism and alcohol and between XPDLys751Gln polymorphism and alcohol increased the onset risk of gastric cancer(S>1, API=0.38). Conclusion The Lys751Gln genotype and susceptibility to gastric cancer in individuals can be relevant. The interaction between carrying Cys or Gln gene-gene and alcohol can increase the susceptibility to gastric cancer.关键词
基因多态性/胃癌/遗传易感性Key words
Polymorphism/Gastric cancer/Genetic susceptibility分类
医药卫生引用本文复制引用
于兆亚,汤静..hOGG1基因多态性与胃癌遗传易感性的关系[J].中国医药科学,2013,(20):27-28,32,3.
