摘要
Abstract
Objective To evaluate the effect of saxagliptin in combination with metformin on β cell functions in newly diagnosed patients with type 2 diabetes. Methods It was a randomized observational study. At baseline,a total of 66 newly diagnosed patients with type 2 diabetes were randomly assigned to metformin plus saxagliptin therapy(group A,n=33) or metformin monotherapy(group B,n=33). The observational period lasted for 24 weeks. Repeated measures were utilized to evaluate changes from baseline in fasting plasma glucose(FPG),2-hour postprandial plasma glucose (2hPG), serum insulin concentrations, hemoglobin A1C(HbA1C),homeostasis model assessment index of insulin resistance (HOMA-IR) and β cell function (HOMA-β).HOMA-β was compared between group A and B. Results The levels of FPG,2hPG, HbA1C and HOMA-IR decreased significantly in both groups 24 weeks after the initiation (P<0.05).HOMA-β increased significantly in both groups (P<0.05).Compared with group B, there was significant reductions in FPG, 2hPG and HbA1C in group A,and increase in HOMA-β(P<0.05). Conclusion Saxagliptin as an add-on therapy to metformin not only benefits glucose control but also improvesβcell function.关键词
沙格列汀/二甲双胍/2型糖尿病/β细胞功能Key words
Saxagliptin/Metformin/Type 2 diabetes mellitus/Beta cell function分类
医药卫生
