中国医药科学Issue(21)：46-48,3.
放疗联合替莫唑胺对照尼莫斯汀同步化疗治疗脑恶性胶质瘤疗效观察
Efficacy observation of radiotherapy combined with temozolomide and radiotherapy combined with nimustine in the treatment of malignant glioma
胡永强 1杨海林 1王广才 2魏少贤 1张孝勇 1尚喜晓 1李训东 1张军1
作者信息
- 1. 濮阳市油田总医院放疗科，河南濮阳457001
- 2. 河南省濮阳市第五人民医院放射科，河南濮阳457001
- 折叠
摘要
Abstract
Objective To observe the short-term efficacy and safety of radiotherapy combined with temozolomide(TMZ) and radiotherapy combined with nimustine(ACNU) after the surgery for glioma. Methods Thirty-six patients with high grade glioma diagnosed by postoperative pathological report were divided into 18 cases of the radiotherapy combined with temozolomide treatment group(RT-TMZ group) and 18 cases of the radiotherapy combined with nimustine treatment group(RT-ACNU group) according to the patient's wishes and economic situation. The patients in two groups were applied temozolomide(TMZ) or nimustine(ACNU) for 4 ~ 6 cycles of chemotherapy respectively, meanwhile implemented radiotherapy with 60Gy total exposure dose, 2Gy every time, once a day, 5 times every week. Results The patients in two groups did not appear aboveⅢdegrees toxic reactions during the observation period, the incidence of I~Ⅱ degree adverse reactions in the RT-TMZ group was lower than that in the RT-ACNU group(P < 0.05). The effective rate and control rate in the RT-TMZ group(83.3%, 88.9%) were significantly higher than those in the RT-ACNU group(55.6%,66.7%), and the differences were statistically significant between two groups(P<0.05). The 1 year and 2 years survival rate in the RT-TMZ group(77.8%, 55.6%respectively) were superior to those in the RT-ACNU group(61.1%, 33.3%respectively),P<0.05. Conclusion Compared with the radiotherapy combined with ACNU, the radiotherapy combined with TMZ after the surgery for patients with glioma is safer and more effective. The postoperative radiotherapy combined with TMZ for patients with malignant glioma has better efficacy, minor toxic reactions, and oral TMZ is easy to use, it will be good prospects for clinical application.关键词
脑胶质瘤/放射治疗/替莫唑胺/尼莫司汀Key words
Glioma/Radiotherapy/Temozolomide/Nimustine分类
医药卫生引用本文复制引用
胡永强,杨海林,王广才,魏少贤,张孝勇,尚喜晓,李训东,张军..放疗联合替莫唑胺对照尼莫斯汀同步化疗治疗脑恶性胶质瘤疗效观察[J].中国医药科学,2013,(21):46-48,3.
