中国医药科学Issue(23)：57-58,74,3.
系统性红斑狼疮患儿外周血淋巴细胞亚群变化
The change of peripheral blood lymphocyte subsets in children with systemic lupus erythematosus
高姗 1张惠君 2朱海燕 1张秋业1
作者信息
- 1. 青岛大学附属医院小儿心肾免疫科，山东青岛266003
- 2. 青岛大学附属医院放射科，山东青岛266003
- 折叠
摘要
Abstract
Objective To study the characteristics of changes of peripheral blood lymphocyte subsets in children with systemic lupus erythematosus(SLE). Methods 24 children with SLE and 20 healthy children were selected as the study objects, the peripheral blood lymphocyte subsets in children were detected by using the FCM, then the test results of the two groups were analyzed and compared. Results The percentages of peripheral blood CD4+CD25+ T cells and NK cells in children with SLE were significantly lower than those in the control group(t=2.480,3.773, P<0.05), while the percentages of CD8+ T cells, activated T cells and B cells in children with SLE were significantly higher(t=3.470, 4.779,2.480, P<0.05 or P<0.01). Conclusion The dysfunctional peripheral blood lymphocyte subsets in children with SLE, decreasing regulatory T cells and NK cells, increasing B cells and excessive activation of T cells, which may play an important role in the pathogenesis of SLE.关键词
系统性红斑狼疮/儿童/淋巴细胞亚群Key words
Systemic lupus erythematosus/Child/Lymphocyte subsets分类
医药卫生引用本文复制引用
高姗,张惠君,朱海燕,张秋业..系统性红斑狼疮患儿外周血淋巴细胞亚群变化[J].中国医药科学,2013,(23):57-58,74,3.
