摘要
Abstract
Objective To evaluate in vitro and in vivo antibacterial activities of cefetamet pivoxil hydrochloride against clinical isolates and compare with Cefaclor. Methods Minimal inhibitory concentrations(MICs)tests were determined by means of broth-dilutions methods.The affecting factors were also determined.Drugs were administered by gavage 1 h and 6 h after mice were infected intraperitoneally with 1 mL of bacterial suspension.The median efective dose (ED50) was calculated by the probit method. Results The results indicated that cefetamet showed good activity against gram-positive bacteria.The MIC50 value was 0.25μg/mL for both Streptococcus pneumoniae and Beta hemolytic streptococcus . Cefetamet also showed good activity against gram- negative bacteria.It was also active against gram-negative bacteria. The MIC50 value was 0.25,0.5,0.5,and 0.5μg/mL for Gonococcus,Klebsiella pneumonia,Bacillus dysenteriae and Haemophilus influenzae.The protective effects of cefetamet pivoxil hydrochloride against experimental systemic infections in mice were observed.ED50 of cefetamet pivoxil hydrochloride agains Staphylococcus anreus and Eescherichia coli were 24.6 and 9.3 mg/kg,respectively.Antibacterial activity of cefetamet pivoxil hydrochloride against Staphylococcus aureus was weaker than cefaclor, but its antibacterial activity against Eescherichia coli was more active than cefaclor. Conclusion Cefetamet pivoxil hydrochloride showed a good activity against clinical isolates.关键词
头孢他美酯/抗菌活性/体内/体外Key words
Cefetamet pivoxil hydrochloride/Antibacterial activities/In vitro/In vivo分类
医药卫生
