中国医药科学Issue(3)：9-11,17,4.
含RGD修饰的丹参酮ⅡA多级靶向纳米粒的制备及工艺优化
Preparation and optimization of TSIIA-loaded mPEG-PLGA-PLL-cRGD nanoparticles
摘要
Abstract
Objective To study the targeting efficacy of Tanshinone Ⅱ A(TSⅡA) nanoparticles(TNP). Methods TNP was prepared by a oil-in-water (O/W) emulsion/solvent evaporation method and orthogonal design for optimization of formulation and technology. Results The optimum formula and preparation method NP were: TSIIA 1mg/Ml, mPEG-PLGA-PLL 20mg/mL, O/W 1 ︰ 10, with sonicate time of 20×5s and sonicate intensity of 200W. Conclusion The TNP has high entrapment efficiency and drug loading, which provides an extensive prospect for clinical application of TSⅡA.关键词
丹参酮ⅡA/载药纳米粒/RGD/肿瘤靶向Key words
TanshinoneⅡA/Nanoparticles/cRGD/Tumor target分类
化学化工引用本文复制引用
王炎,宋大迁,王青,冯媛媛,许玲,范忠泽,李琦..含RGD修饰的丹参酮ⅡA多级靶向纳米粒的制备及工艺优化[J].中国医药科学,2014,(3):9-11,17,4.基金项目
国家自然科学基金资助项目（81001594）；上海市科学技术委员会科研计划项目（114119a9500）；上海市科学技术委员会科研计划项目（11nm0504500）；上海市卫生局青年科研项目（2009Y091）。 （）
