中国医药科学Issue(3)：18-21,4.
Sox9和Ⅱ型胶原蛋白在人腰椎间盘退变中的表达及意义
Expressions of Sox9 and Col2a1 in human degenerated lumbar intervertebral disk
摘要
Abstract
Objective To study expressions of Sox9 and Col2a1 in human degenerated lumbar intervertebral disk. Methods Immunohistochemestry was used to evaluate expression of Sox9 and Col2a1 in human degenerated and nomal lumbar intervertebral disk. Results The positive immunostaining rate of Sox9 was 20.0%(6/30) in experimental group and 76.7% (23/30) in control group. There were significant differences(P < 0.05) between two groups. The positive immunostaining rate of Col2a1 was 33.3% (10/30) in experimental group and 83.3% (25/30) in control group.There were significant differences(P < 0.05) between two groups.In the 30 degenerated lumbar intervertebral disks, 6 cases of Sox9 positive expression included 1 case of Col2a1 negative. 10 cases of Col2a1 positive expression included 5 cases of Sox9 negative expression. 5 cases were both positive while 19 cases were both negative. There was a positive correlation between the expressions of Sox9 and Col2a1(P < 0.05). Conclusion Decrease of Sox9 and Col2a1 is related to the degeneration of lumbar intervertebral disk. Sox9 may downregulate Col2a1 directly,resulted in degeneration of lumbar intervertebral disk.关键词
Sox9/Ⅱ型胶原蛋白/腰椎间盘退变/免疫组织化学Key words
Sox9/Col2al/Lumbar intervertebral disk degeneration/Immunohistochemestry分类
医药卫生引用本文复制引用
黄秀芳,原向伟..Sox9和Ⅱ型胶原蛋白在人腰椎间盘退变中的表达及意义[J].中国医药科学,2014,(3):18-21,4.基金项目
广东省江门市科技计划项目（江科20084029）。 （）
