中国医药科学Issue(4)：32-34,38,4.
壮筋续骨汤对骨折大鼠血清CT和维生素D3水平的影响和意义
Effect and significance of ZJXG decoction on the serum levels of CT and VitD3 in femur fracture rats
王祥杰 1周缜 2王功国 1祝汉忠 2潘月兴1
作者信息
- 1. 山东省日照市中医医院骨伤科，山东日照276800
- 2. 青岛大学医学院中西医结合中心，山东青岛266021
- 折叠
摘要
Abstract
Objective To investigate the effects of Zhuang Jin Xu Gu(ZJXG) decoction on the serum levels of calcitonin(CT) and active vitamin D3(VitD3) in femoral fracture rats. Methods Femur fractures were generated in 72 male adult Wistar rats by cutting femur transversely at middle point. ZJXG decoction was administered orally after surgery for 28d. The healing process was analyzed by X-ray. The serum levels of CT and VitD3 were assessed by enzyme linked immunobsorbent assay(ELISA). Results X-ray indicated that the fracture line of the femoral fracture-end was clear at 7d, fibrous callus tissue formed at 14d, Ca2+salt deposited at 21d and osseous callus tissues formed at 28d. During fracture 7-21d, no difference of the callus tissues structure existed between model and treatment groups, but in treatment group it was better than that in model group at 28d. ELISA results showed that the serum levels of CT and VitD3 were higher than those in control group at 7-28d(P<0.05). There were no significant difference between model and treatment groups at 7-21d, but in treatment group it was higher than that in model group at 28d(P<0.05). Conclusion ZJXG decoction could enhance the fracture healing by reducing the decomposition of CT and VitD3 in femur fracture rats.关键词
壮筋续骨汤/骨折/降钙素/维生素D3/大鼠Key words
ZJXG decoction/Fracture/Calcitonin/Vitamin D3/Rats分类
医药卫生引用本文复制引用
王祥杰,周缜,王功国,祝汉忠,潘月兴..壮筋续骨汤对骨折大鼠血清CT和维生素D3水平的影响和意义[J].中国医药科学,2014,(4):32-34,38,4.
