中国医药科学Issue(4)：64-67,4.
基于Brij97液晶的胰岛素皮下注射给药载体制备
Brij97 based liquid crystalline for sustained subcutaneous delivery of insulin
马爱明 1蒋曙光 2黄铃 1周建平1
作者信息
- 1. 中国药科大学药剂教研室，江苏 南京 210009
- 2. 中国药科大学 江苏 南京 210009
- 折叠
摘要
Abstract
Objective To develop non-ionic surfactant polyoxyethylene (10) oleyl ether(Brij97)fluid precursor formulations for subcutaneous injection as a strategy to sustain the release of insulin. Methods To study the phase transition behavior of these formulations, different content of water was added, the resulting systems were characterized by polarized light microscopy. Results Two formulations containing Brij97-IPM-water (18︰2︰3)(w/w, referred to as 10%IPM) Brij97-IPM-water(4 ︰ 1 ︰ 1) (w/w, referred to as 20%IPM) were chosen to study insulin release kinetic. Fluid precursor formulations were transformed into hexagonal phases in one hour after contact with water. Water uptake followed second-order kinetics. Conclusion Drug release is prolonged by the precursor formulations, but the release from 20%IPM is significantly lower than 10%IPM after 24h, This indicate that capacity of sustained release increased with the increase of lipophilic additive. These results suggest the potential of BRIJ-based precursor formulations for sustained insulin release.关键词
Brij97/液晶/胰岛素/皮下注射/缓释Key words
Brij97/Liquid crystal/Insulin/Subcutaneous injection/Sustained release分类
化学化工引用本文复制引用
马爱明,蒋曙光,黄铃,周建平..基于Brij97液晶的胰岛素皮下注射给药载体制备[J].中国医药科学,2014,(4):64-67,4.
