中国医药科学Issue(4)：100-102,3.
喹硫平治疗帕金森病合并精神障碍的疗效观察
Clinical effect observation of quetiapine in the treatment of Parkinson's disease complicated with mental disorder
黄德 1邹俊民 1李赣东1
作者信息
- 1. 广东省茂名农垦医院神经内科，广东高州525200
- 折叠
摘要
Abstract
Objective To investigate the efficacy and adverse reactions of quetiapine in the treatment of Parkinson's disease(PD) complicated with mental disorder. Methods 78 patients with Parkinson's disease complicated with mental disorder were included. All of them had psychological and behavioral abnormality for more than one month,including 42 cases with positive symptom and 36 cases with negative symptom. 78 patients were randomly divided into two groups with 40 cases in the treatment group and 38 cases in the control group. The treatment group was given 50~400mg of Quetiapine per day as well as anti-Parkinson drugs and then was observed for 8 weeks while the control group only received anti-Parkinson drugs. Before and after the treatment,the unified parkinson's disease Rating Scale(UPDRS) was adopted for functional assessment,the positive and negative syndrome scale(PANSS) for the evaluation of mental disorder and efficacy and the treatment emergent symptom scale(TESS) for assessing the adverse reactions. Results After the treatment, the PANSS score decreased in both groups with greater drop in the treatment group. There was statistically significant difference in both groups(P < 0.01). The UPDRS score decreased in both groups after the treatment with no statistically significant difference(P>0.05). There were fewer adverse reactions in the treatment group and no severe adverse reactions occurred. Conclusion Quetiapine should be promoted clinically with reliable efficacy in Parkinson's disease complicated with mental disorder, fewer adverse reactions and good safety.关键词
喹硫平/帕金森病/精神障碍Key words
Quetiapine/Parkinson's disease/Mental disorder分类
医药卫生引用本文复制引用
黄德,邹俊民,李赣东..喹硫平治疗帕金森病合并精神障碍的疗效观察[J].中国医药科学,2014,(4):100-102,3.
