中国中西医结合外科杂志Issue(6)：660-664,5.DOI:10.3969/j.issn.1007-6948.2013.06.016
自体表皮细胞-纤维蛋白膜创面移植治疗大鼠烧伤
Treatment of Burn by Transplanting Fibrinous Membrane with Autologous Epidermal Cells on Raw Surface
摘要
Abstract
Objective To observe the treatment effect of skin defect by transplanting fibrinous membrane with autologous epidermal cells to burn wounds in rats, and to look for new ways to treat the burn caused by large area skin defect. Methods Twenty healthy Wistar rats were randomly divided into burn skin defect mod-ule group and fibrinous membrane with autologous epidermal cells transplanting group. The optimum epidermal cells inoculation density on fibrinous membrane was calculated. The wound healing and the wound contraction ratio after fibrinous membrane with autologous epidermal cells transplantation were observed. Results The best density on fibrinous membranes with epidermal cells was 2.5x104/cm2, burn skin defect module group rats wound healed completely spening an average of about 22.3 days, and the fibrinous membrane with autologous epidermal cells transplantation treatment group rats wound healed completely time was about 18.1 days on aver-age; the wound shrinkage rate of burn skin defect module group rats was(70 ± 5)% , and transplantation group rats was(20±5)%. Conclusion The fibrinous membrane with autologous epidermal cells can be used to cover large area skin defect caused by burn, and can prevent scar formation, reduce wound shrinkage rate, to acceler-ate wound healing, thus playing an important role in curing large burn skin defect.关键词
烧伤/大鼠/自体表皮细胞-纤维蛋白膜/移植Key words
Wistar rats/burn/fibrinous membrane with autologous epidermal cells/transplant分类
生物科学引用本文复制引用
陈子英,王晓晔,崔华雷..自体表皮细胞-纤维蛋白膜创面移植治疗大鼠烧伤[J].中国中西医结合外科杂志,2013,(6):660-664,5.
