中国中西医结合外科杂志Issue(1)：35-37,3.DOI:10.3969/j.issn.1007-6948.2014.01.010
托烷司琼对手术后曲马多自控静脉镇痛患者免疫功能的影响
Effect of Tropisetron Hydrochloride on Immune Function of Tramadol for Postoperative Patient-controlled Intravenous Analgesia
李琼珍 1肖旺频 1周清河 1雷龙1
作者信息
- 1. 浙江省嘉兴市第二医院麻醉科 嘉兴 314000
- 折叠
摘要
Abstract
Objective To investigate the effect of Tropisetron Hydrochloride on the immune function of tra-madol for postoperative patient-controlled intravenous analgesia. Methods Forty patients were randomly as-signed into two groups, connecting the PCIA pump after given the load quantity. Blood samples were collected before induction of anaesthesia and after operation for 0 h, 24 h, 48 h, respectively. The T-lymphocyte subsets and natural killer cells(NK)were measured by flow cytometry. Results The incidences of nausea and vomiting were higher in control group than those in observation group(P<0.05) . In both groups,the amounts of CD3+ and CD4+lymphocytes decreased significantly at 0 h, 24 h and 48 h after operation than before anaesthesia(P<0.05). the amounts of NK cells(CD16+、CD56+/CD45+) and CD4+/CD8+ also decreased significantly at 0 h and 24 h after operation than before anaesthesia(P<0.05). Compared to the observation group ,the amounts of CD16+,CD56+/CD45+, CD3+, CD4+ and CD4+/CD8+ increased significantly at 24 h after operation(P<0.05). In control group, the amounts of CD16+, CD56+/CD45+and CD4+/CD8+recovered to preanaesthesia level at 48 h, while in observa-tion group, they were still lower than preanaesthesia levels(P<0.05). Conclusion Tropisetron Hydrochloride reduces the incidence of vomiting induced by tramadol but not beneficial to recover the cell-immunity of pa-tients suffering from gastric cancer surgery.关键词
术后镇痛/托烷司琼/曲马多/胃癌根治术/免疫功能Key words
Postoperative analgesia/tropisetron hydrochloride/tramadol/radical gastrectomy/immune function分类
医药卫生引用本文复制引用
李琼珍,肖旺频,周清河,雷龙..托烷司琼对手术后曲马多自控静脉镇痛患者免疫功能的影响[J].中国中西医结合外科杂志,2014,(1):35-37,3.
