中国中西医结合外科杂志Issue(2)：137-140,4.DOI:10.3969/j.issn.1007-6948.2014.02.009
氢化可的松在腹腔镜治疗皮质醇增多症围手术期的应用
Application of Hydrocortisone during Perioperation of Cushing's Syndrome after Laparoscopic Opera-tion
李路鹏 1汤坤龙 2李黎明 3林毅3
作者信息
- 1. 天津医科大学研究生院 天津 300070
- 2. 天津医科大学总医院 天津 300052
- 3. 天津医科大学总医院 天津 300052
- 折叠
摘要
Abstract
Objective To investigate the effect of application of hydrocortisone in hormone replacement therapy during perioperation of Cushing's syndrome after laparoscopic operation. Methods A retrospective analysis about the data and outcome of 36 cases of Cushings’s syndrome treated by intravenous dripping and oral hydrocortisone hormone replacement therapy during perioperation after laparoscopic surgery. One hundred mg hydrocortisone was given by intravenous injection during removal of adrenal adenoma,followed by 100 mg given every 12 hours at the same day,then 100 mg every 12hours on the first day and 100 mg daily on the second day after operation. Oral hydrocortisone 40 mg was given three times daily on the second day,followed by a reduction of 20 mg daily until a maintenance dosage (20 mg) was reached. After laparoscopic surgery, the clinical symptoms were closely observed, and the blood and urine cortisol levels were intermittentty monitored to evaluate the therapeutic effect of the hormone re-placement therapy. Results Two cases had slight cortical dysfunction symptoms; six patients had blood corti-sol levels lower than those of the first and second days after surgery(P<0.05); on the seventh day reduced sig-nificantly below the normal range; the serum potassium level of postoperation was significantly higher than that of preoperation(p<0.05); the urinary cortisol level of postoperation was significantly higher(P<0.05); the se-rum cortisol level began to reduce significantly on the second day after surgery(P<0.05). Conclusion The effect of hydrocortisone in hormone replacement therapy during perioperation of Cushing's syndrome after laparo-scopic operation is safe and feasible.关键词
皮质醇增多症/腹腔镜/氢化可的松/激素替代治疗Key words
Cushing syndrome/laparoscopy/hydrocortisone/hormone replacement therapy分类
医药卫生引用本文复制引用
李路鹏,汤坤龙,李黎明,林毅..氢化可的松在腹腔镜治疗皮质醇增多症围手术期的应用[J].中国中西医结合外科杂志,2014,(2):137-140,4.
