中国中医药信息杂志Issue(7)：35-37,3.DOI:10.3969/j.issn.1005-5304.2013.07.014
葛根芩连方抗Wa株轮状病毒的药效学研究
Effect of Gegen Qinlian Decoction on Rotavirus-inducing Diarrhea in Neonatal Mice
摘要
Abstract
Objective To investigate the anti-rotavirus effect of Gegen Qinlian decoction on rotavirus (RV)-inducing diarrhea neonatal mice model, and provide evidences for pharmacological and pharmacodynamic studies. Methods Neonatal diarrhea mice model of Kunming family infected with RV-Wa was developed. Symptom, diarrhea ratio and severity level, histological changes of neonatal mice’s small intestine and lung was assessed after Gegen Qinlian decoction (0.78 g/kg) treatment. Results Diarrhea ratio, diarrhea severity level, histological changes of neonatal mice’s small intestine and lung were obviously decreased after Gegen Qinlian decoction (0.78 g/kg) treatment. Conclusion Gegen Qinlian decoction has anti-rotavirus effect on RV induced diarrhea.关键词
葛根芩连方/轮状病毒/腹泻/小鼠Key words
Gegen Qinlian decoction/rotavirus/diarrhea/mice分类
医药卫生引用本文复制引用
宋丽军,赵文昌,谭晓梅,杨蒙蒙,罗佳波..葛根芩连方抗Wa株轮状病毒的药效学研究[J].中国中医药信息杂志,2013,(7):35-37,3.基金项目
国家自然科学基金(81173636)；广东省自然科学基金(S2011040005339)；广东省中医药局科研课题(2010193)；东莞市高等院校科研机构科技计划(201010815204)；湛江市科技项目(2010C3102001)；广东医学院博士启动项目(XB1005) （81173636）
