中国中医药信息杂志Issue(11)：34-36,3.DOI:10.3969/j.issn.1005-5304.2013.11.013
陈皮半夏对颈动脉硬化家兔血管细胞黏附分子-1及基质金属蛋白酶-9表达的影响
Effect of Tangerine Peel and Pinellia Ternata on Expression of VCAM-1 and MMP-9 in Carotid Atherosclerosis Rabbits
摘要
Abstract
Objective To research the influence of tangerine peel and pinellia ternata on the expression of VCAM-1 and MMP-9 in carotid atherosclerosis rabbits, and explore its mechanism. Methods Totally 25 male rabbits were divided into control group, model group and Chinese medicine group. Control group was treated with basic diet, model group and Chinese medicine group were treated with both high-fat diet and carotid artery intima-air drying technique. Chinese medicine decoction group was treated with tangerine peel and pinellia ternata decoction, as 10, 8, 6 mL/kg, for 4 weeks. Then the right carotid was cut and fixed, and pathological changes were observed by HE staining. The expressions of VCAM-1 and MMP-9 were observed by immunol histochemistry SABC method. Results Compared with control group, the expression of VCAM-1 and MMP-9 in model group was significantly increased (P<0.01). And compared with model group, tangerine peel and pinellia ternata decoction significantly restrained VCAM-1 and MMP-9 expression (P<0.05). Conclusion Tangerine peel and pinellia ternata could restrained VCAM-1 and MMP-9 expression in carotid atherosclerosis rabbits, suggesting that its mechanism may be related with inhibiting vascular inflammatory reaction and stabilizing plaques.关键词
陈皮/半夏/颈动脉硬化/血管细胞黏附分子-1/基质金属蛋白酶-9/兔Key words
tangerine peel/pinellia ternate/carotid atherosclerosis/VCAM-1/MMP-9/rabbits分类
医药卫生引用本文复制引用
陈文强,黄小波,王宁群,陈玉静,吴犀翎..陈皮半夏对颈动脉硬化家兔血管细胞黏附分子-1及基质金属蛋白酶-9表达的影响[J].中国中医药信息杂志,2013,(11):34-36,3.基金项目
国家自然科学基金(30801481,81102624)；北京市科技新星项目(2008A090)；北京市中医药科技项目(JJ2009-037) （30801481,81102624）
