中国中医药信息杂志Issue(1)：65-68,4.DOI:10.3969/j.issn.1005-5304.2014.01.020
寿胎丸对复发性流产小鼠蜕膜组织α-烯醇化酶表达的影响
Effect of Shoutaiwan on Expression of α-enolase in Decidua Tissue of Recurrent Abortion Mice
摘要
Abstract
Objective To observe the effect of Shoutaiwan on the expression ofα-enolase in the decidua tissue of recurrent abortion mice. Methods The abortion-prone CBA/J × DBA/2 matings were established as the model of recurrent abortion and the nonabortion-prone CBA/J×BALB/C matings were used as the model of normal pregnancy. The model of recurrent abortion CBA/J × DBA/2 of pregnant mice were randomly divided into model group and Shoutaiwan high-, medium-, low-dose groups, pregnant mice of every group were orally administrated in different doses. On the 14th day of pregnancy, the mice were killed. The expression ofα-enolase was detected by using immunohistochemical method and Western Blot. Results α-enolase expression in the model group was significantly higher than the normal pregnancy group (P<0.01). Compared with the model group, Shoutaiwan low-, medium- and high-dose group significantly decreasedα-enolase expression of pregnant mice (P <0.01). Compared with high-dose group, Shoutaiwan medium-and low-dose group showed no significant difference (P>0.05). Conclusion Shoutaiwan could down-regulate the expression ofα-enolase in the decidua tissues of recurrent abortion mice, which may be one of its mechanisms of preventing miscarriage.关键词
寿胎丸/复发性流产/蜕膜组织/α-烯醇化酶/小鼠Key words
Shoutaiwan/recurrent abortion/decidua tissues/α-enolase/mice分类
医药卫生引用本文复制引用
谭展望,雷磊,李慧芳,朱伟,孟琼,罗蕾,卢丽丽..寿胎丸对复发性流产小鼠蜕膜组织α-烯醇化酶表达的影响[J].中国中医药信息杂志,2014,(1):65-68,4.基金项目
国家自然科学基金面上项目(30973771)；教育部博士点基金博士导师项目(20094323110004) （30973771）
