中国中医药信息杂志Issue(4)：49-51,52,4.DOI:10.3969/j.issn.1005-5304.2014.04.016
糖痹康对糖尿病周围神经病变大鼠血浆β-内啡肽的影响
Effect of Tangbikang on Level of Plasma β-EP of Diabetic Peripheral Neuropathy Rats
摘要
Abstract
Objective To observe the effect of Chinese herbal compound Tangbikang on the level of plasma β-EP of diabetic peripheral neuropathy rats, and to discuss its mechanism of neuroprotection and abirritation. Methods STZ and feeding high fat forage induced diabetic rats were randomly divided into diabetic model group, Mecobalamin group, Tangbikang high dose group, Tangbikang medium dose group, Tangbikang low dose group, with 10 normal rats as control. The control group and model group were daily gavaged with distilled water, Tangbikang groups were given Tangbikang with different dose. Mecobalamin was used as the control medicine. Body weight and FBG was detected every 4 weeks, rats’ unilateral sciatic nerve were taken out at the 16th week. Pathological variation of sciatic nerve was presented by HE staining, and radioimmunoassay method was used to detect the levels of plasma β-EP of diabetic peripheral neuropathy of rats. Results The weight and FBG had obviously changed in the 16th week. Compared with the model group, pathological injury of diabetic peripheral neuropathy rats in the Tangbikang groups were significantly improved. The level ofβ-EP of model group was significantly decreased (P<0.01) compared with normal group. Tangbikang medium and high dose group significantly increased the level of plasma β-EP (P<0.01). Conclusion Chinese herbal compound Tangbikang could reduce the fasting blood glucose, protect nervous system and promote the level of plasmaβ-EP of diabetic peripheral neuropathy rats.关键词
糖痹康/糖尿病/周围神经病变/坐骨神经/β-内啡肽/大鼠Key words
Tangbikang/diabetes mellitus/peripheral neuropathy/sciatic nerve/β-EP/rats分类
医药卫生引用本文复制引用
吕翠岩,李秋明,毛颖秋,刘铜华..糖痹康对糖尿病周围神经病变大鼠血浆β-内啡肽的影响[J].中国中医药信息杂志,2014,(4):49-51,52,4.基金项目
国家科技重大专项-重大新药创制(2012ZX09102201-001)；教育部博士点基金立项课题(20110013130001)；北京中医药大学创新团队项目(2011-CXTD-19)；教育部中医养生学重点实验室(2013-2015)；北京市中医养生学重点实验室(2013-2015) （2012ZX09102201-001）
