中国中医药信息杂志Issue(4)：70-72,3.DOI:10.3969/j.issn.1005-5304.2014.04.022
当归配方颗粒与当归饮片质量比较研究
Comparative Study on Quality of Angelica Formula Particles and Angelica Pieces
摘要
Abstract
Objective To determine the content of ferulic acid, water and extract of Angelica formula particles, provide a reliable method for evaluation and quality control, and compare the quality of Angelica formula particles and Angelica pieces. Methods HPLC method was used with Kromasil C18 column (4.6 mm×250 mm, 5μm), flow rate of 1.0 mL/min, detection wavelength of 316 nm, column temperature at 28 ℃. The mobile phase was acetonitrile-0.05%phosphoric acid in water gradient elution system. Results Ferulic acid showed good linear relationship in the range of 0.033-0.165 μg (r=0.999 8). The average recovery was 98.78% and RSD=0.99%. Angelica formula particles met the quality requirement in the content indicators, the content of ferulic acid was higher than Angelica pieces. Conclusion The HPLC method for determination of ferulic acid in Angelica formula particles is simple and reliable, with good reproducibility, and can be used as the quality control method of Angelica formula particles.关键词
当归配方颗粒/当归饮片/阿魏酸/高效液相色谱法Key words
Angelica formula particles/Angelica pieces/ferulic acid/HPLC分类
医药卫生引用本文复制引用
李越峰,张泽国,徐福菊,金辉,杜丽东,王瑞琼,王继龙,严兴科..当归配方颗粒与当归饮片质量比较研究[J].中国中医药信息杂志,2014,(4):70-72,3.基金项目
教育部科学技术研究重点项目(212186)；甘肃省高等学校基本科研业务费专项资金(2013-2)；甘肃省自然科学基金(1010RJZA212)；甘肃中医学院引进人才科研启动基金(2010-3) （212186）
