中国卒中杂志Issue(1)：13-19,7.DOI:10.3969/j.issn.1673-5765.2014.01.004
卒中后抑郁细胞因子蛋白组学初探
Cytokines Proteomic Study in Post-Stroke Depression:A Preliminary Study
摘要
Abstract
Objective To investigate the association between post-stroke depression (PSD) and the level of cytokines in plasma. Methods Plasma spot signal intensity (SIs) of 120 cytokines were measured by Human Cytokine Antibody Array G-Series 1000 in 12 patients with PSD and 12 non-PSD controls who admitted to the hospital within the ifrst 3 days after stroke onset. The diagnoses of PSD were made in accordance with DSM-IV criteria. The 17-item Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to screen for depressive and anxiety symptoms on days 14 after admission. Results Plasma SIs of 4 cytokines (insulin-like growth factor 1 receptor [IGF-I SR], macrophage inflammatory protein-3 beta [MIP-3 beta], placental growth factor [PIGF], vascular endothelial growth factor [VEGF]) were signiifcantly lower in PSD patients than in non-PSD patients, although these findings were not significant after the false discovery rate (FDR) correction for multiple testing to be applied. No cytokine was independently associated with incidence of PSD at the acute stage of stroke. Plasma SIs of IGF-I SR showed a negative correlation with the Barthel index (r=-0.641, P=0.025) 1 day after admission and showed positive correlations with the HAMD (r=0.478, P=0.005) and HAMA scores (r=0.674, P=0.016) 14 days after admission. Conclusion Plasma levels of cytokines after ischemic stroke can't serve as a biological marker to predict the incidence of PSD. Dysfunction of synaptic plasticity and neurogenesis may play a causative role in PSD.关键词
缺血性卒中/卒中后抑郁/细胞因子/蛋白组学Key words
Ischemic stroke/Post-stroke depression/Cytokine/Proteomics引用本文复制引用
耿磊钰,唐浩,李文平,钱方媛,钱俊峰,李凌江,张志珺..卒中后抑郁细胞因子蛋白组学初探[J].中国卒中杂志,2014,(1):13-19,7.基金项目
国家十二五重点科技项目（新药创制平台，No.2012ZX09506-001-009）国家重点基础研究发展计划(973项目， No.2009CB918303) （973项目， No.2009CB918303）
