中国卒中杂志Issue(4)：278-284,7.DOI:10.3969/j.issn.1673-5765.2014.04.004
不同大血管闭塞性急性缺血性卒中患者静脉溶栓疗效比较
Comparison of Intravenous Thrombolytic Effect of Acute Ischemic Stroke Patients ;with Different Large Vessel Occlusion
摘要
Abstract
Objective To compare the intravenous thrombolytic therapeutic effect of the acute ischemic stroke patients with different large vessel occlusion and to investigate which occlusion subtype of patients are suitable for intravenous thrombolytic treatment. Methods Data were analyzed from the Thrombolysis Implementation and Monitoring of Acute Ischemic Stroke in China (TIMS-China). Patients who accomplished multiple parameter computed tomography (CT) or magnetic resonance (MR) and CT angiography or MR angiography showed large vessel occlusion were included. The safety and efifcacy outcome were compared. Results A total of 122 patients were included. The rates of recanalization were:middle cerebral artery (MCA) occlusion group 55.2%, internal carotid artery (ICA) occlusion group 0%and basilar artery (BA) occlusion group 40%. For the functional independence outcome at 90 days, MCA occlusion group was significantly better than ICA occlusion group (53.9%vs 21.1%, P=0.007, [odds ratio, OR]=5.68). For excellent recovery outcome at 90 days, MCA occlusion group was also signiifcantly better than ICA occlusion group (42.7%vs 21.1%, P=0.041, OR=3.76). For mortality, MCA group was signiifcantly lower than ICA group (4.5%vs 47.4%, P<0.001, OR=0.03). There were no signiifcant differences between MCA group and ICA group in the symptomatic intracranial hemorrhage (1.1%vs 0%, P=0.962). Conclusion The intravenous thrombolytic therapeutic effect of the acute ischemic stroke patients with different large vessel occlusion was signiifcantly different. The recanalization rate of MCA occlusion group was highest, and the therapeutic effect was signiifcantly better than ICA occlusion group.关键词
急性缺血性卒中/大血管闭塞/溶栓/疗效Key words
Acute ischemic stroke/Large vessel occlusion/Thrombolytic treatment/Therapeutic effect引用本文复制引用
廖晓凌,王伊龙,潘岳松,王春娟,赵性泉,王春雪,刘丽萍,王拥军..不同大血管闭塞性急性缺血性卒中患者静脉溶栓疗效比较[J].中国卒中杂志,2014,(4):278-284,7.基金项目
北京市科委2011年度科技计划重大项目--《缺血性脑卒中高危预警体系建立和规范研究》（No.D111107003111007）“十二五”国家科技支撑计划（2011BAI08B02）“十一五”国家科技支撑计划 （）
