中华耳科学杂志Issue(3)：432-434,3.DOI:10.3969/j.issn.1672-2922.2013.03.021
应用3.0T高分辨率磁共振成像活体动态观测豚鼠内耳内淋巴液
In vivo Dynamic Changes of Endolymph in Guinea Pigs on High-Resolution Magnetic Resonance Hydrography
摘要
Abstract
Objectives To investigate whether a clinical 3.0T MRI system can distinguish endolymph from perilymph in vivo in guinea pigs. Methods Five guinea pigs were injected with Gd-DTPA via the internal jugular vein (3 ml/kg) at the mo-ment when inner ear volume scans on a 3.0T MRI system were completed. Susequent inner ear volume scans were taken every 30 minutes for 240 min to detect changes of endolymph and perilymph. Results Only outlines of the cochlea and vestibule were visible before Gd-DTPA injection with no distinction between endolymph and perilymph. Uptake of Gd-DTPA firstly oc-curred in the vestibule and the basal turn, and in the apex of cochlea 30 min after the injection. At 120 min after injection, Gd-DTPA uptake was seen throughout the entire inner ear with clear imaging. Conclusions Endolymph of inner ear can be distinguished from the perilymph on a clinical 3.0T MRI system, which may provide great convenience for the study of endo-lymphatic hydrops.关键词
内淋巴液/磁共振成像/钆喷酸葡胺/豚鼠Key words
endolymph/MRI/Gd-DTPA/guinea pig分类
医药卫生引用本文复制引用
孟令照,李保卫,吴玮,曾亚伟,郭庆,金真,韩浩伦,王刚,孙建芝,王鸿南..应用3.0T高分辨率磁共振成像活体动态观测豚鼠内耳内淋巴液[J].中华耳科学杂志,2013,(3):432-434,3.基金项目
十二五全军重大科研课题（编号AWS11J003）,解放军306医院院级课题（编号11QN08）。 （）
