中华耳科学杂志Issue(4)：593-596,4.DOI:10.3969/j.issn.1672-2922.2013.04.032
耳蜗毛细胞严重缺失后螺旋神经节细胞的病理变化
The Fate of the Spiral Ganglion Cells After the Cochlear Hair Cells Serious Injuried
摘要
Abstract
Objective To study morphological changes of spiral ganglion cells (SGN) following severe cochlear hair cells injury. Methods Guinea pigs were given kanamycin sulfate (1000 mg/kg) intramuscularly followed by furosemide (100 mg/kg) intravenously 2 hours later. Auditory brainstem responses (ABRs) and cochlear morphology were examined at 3 days, 7 days, 1 month and 2 months respectively after the treatment. Results ABR thresholds were greatly elevated after the treatment, with no significant difference among the different time groups. Scanning electron microscopy revealed severe damage to cochlear hair cells, especially out hair cells (OHC) after 7 days. There was also extensive loss of inner hair cells in animals with severe auditory function damage while supporting cells in the organ of Corti were preserved. The SGN showed no change on Day 7, al-though severe SGN loss was seen after 1 month, with total collapse of the organ of Corti. Conclusion Drug-induced hearing loss starts with hair cell loss, followed by SGN loss. In addition, the extent of SGN damage seems to correlate to time lapse after drug administration and can take years to develop, which may provide a time window for cochlear implant.关键词
卡那霉素/速尿/毛细胞/螺旋神经节细胞Key words
kanamycin/furosemide/hair cells/spiral ganglion cells分类
医药卫生引用本文复制引用
王建军,毛华杰,董吕华,翟所强,马龙..耳蜗毛细胞严重缺失后螺旋神经节细胞的病理变化[J].中华耳科学杂志,2013,(4):593-596,4.基金项目
由浙江省台州市科技局课题资助，项目编号100KY48 （）
