转化医学杂志Issue(2)：65-68,4.DOI:10.3969/j.issn.2095-3097.2014.02.001
人源性肿瘤组织异种移植模型的研究进展
The research progress of patient-derived tumor xenografts
摘要
Abstract
Patient-derived tumor xenografts (PDTX)which graft human tumor material into immunocompetent or immunodeficient mouse overcome the disadvantages of cell line-derived xeno-grafts.Patient-derived tumor xenografts maintain the cell differentiation and morphology,the archi-tecture,and molecular signatures of the original patient tumors.Vasculature,stroma,central necro-sis,and peripheral growth occur in tumor bearing mice in a way that is similar to that of the patient′s tumor,then there will be a higher correlation between drug response of tumor xenografts with the corresponding original tumors.But beyond that,patient-derived tumor xenograft models that are clin-ically representative of each major human cancer type would largely increase the success in identi-fying new active agents for targeting particular tumours.Therefore,these individualised models of human cancers would have an important significance for preclinical tumor assessment,treatment and prognosis and greatly facilitate selecting the best therapy for each individual patient.关键词
人源性肿瘤组织异种移植/原发肿瘤/个体化治疗Key words
Patient-derived tumor xenografts(PDTX)/Primary tumor/Individual treatment分类
医药卫生引用本文复制引用
刘情,郑琳,张灏..人源性肿瘤组织异种移植模型的研究进展[J].转化医学杂志,2014,(2):65-68,4.基金项目
国家自然科学资金资助项目 （）
