广东海洋大学学报Issue(4)：70-75,6.
常用剂量氟苯尼考在罗非鱼肝脏和肾脏中的消除规律及组织学影响
Elimination Pattern and Histological Effect of Usual Dosage of Florfenicol in Liver and Kidney of Tilapia (Oreochromis niloticus)
摘要
Abstract
The pharmacokinetics and elimination of florfenicol in liver and kidney of tilapia (Oreochromis niloticus) single-orally administered 12 mg/kg of florfenicol at water temperature of 28 ℃were studied by HPLC in different periods. The results showed that the pharmacokinetic parameters in the liver and kidney were all in accord with the pharmacokinetic one-compartment model. The elimination speed of florfenicol in liver was faster than that in kidney,and the elimination half-life (T1/2β) of florfenicol in liver and kidney were 4.89 h and 15.93 h, respectively. The Tmax of florfenicol in liver was 5.43 h;59 hours after administration, the concentrations of florfenicol in liver and kidney were all less than 0.8 µg/g. Liver and kidney extracted from test fish continuous administrated with 12mg/kg florfenicol for 7 days were observed histologically. The results showed that no histopathological change was found in liver and kidney. The inhibitory effect of florfenicol to 6 kinds of pathogenic bacteria was detected, and the results showed MIC≤4 mg/L in all tested bacteria. This study indicated that florfenicol eliminate fast, has less residue and cause no histopathological damage in tilapia. As evidenced by the advantages above, it has good antibacterial effects on common pathogens in tilapia.关键词
罗非鱼/氟苯尼考/消除半衰期/一室模型/病理组织学变化/最小抑菌浓度Key words
Oreochromis niloticus/Florfenicol/elimination half-life/one-compartment model分类
农业科技引用本文复制引用
罗理,王伟利,姜兰,谭爱萍,邓玉婷,赵飞..常用剂量氟苯尼考在罗非鱼肝脏和肾脏中的消除规律及组织学影响[J].广东海洋大学学报,2013,(4):70-75,6.基金项目
公益性行业（农业）科研专项（201203085）；广东省科技计划项目 （）
