神经药理学报Issue(3)：1-6,6.
金莲花中荭草苷和牡荆苷对D-半乳糖致衰老小鼠的抗氧化作用
Antioxidant Effects of Orientin and Vitexin in Trollius Chinesis in D-galactose-induced Mice Model of Aging
摘要
Abstract
Objective:To study the antioxidant effects of orientin and vitexin from Trollius chinensis Bunge. Methods:Daily intraperitoneal injection of D-galactose for 8 weeks was used to establish experimental aging in mice. Different groups of mice were treated with 40,20 or 10 mg·kg-1 orientin,vitexin,or a positive control(vitamin E)via intragastric administration for an additional 8 weeks. The total antioxidant capacity in the serum,activities of the antioxidant enzyme and the cell membrane transport ion ATP enzyme,and the level of malondialdehyde in the liver,brain and kidneys were determined. Results:Orientin,vitexin,and vitamin E produced a significant increase in total antioxidant capacity,in the serum,and the levels of superoxide dismutase,catalase and glutathione peroxidase,Na+-K+-ATP enzyme,and Ca2+-Mg2+-ATP enzyme in the liver,brain and kidneys. In addition,they significantly reduced the malondialdehyde levels in the liver,brain and kidney. The 40 mg·kg-1 dose of orientin and vitexin had similar antioxidant effects as vitamin E. Conclusion:Orientin and vitexin have anti-aging effects possibly through their antioxidant activities.关键词
荭草苷/牡荆苷/D-半乳糖/抗氧化Key words
orientin/vitexin/D-galactose/antioxidation分类
医药卫生引用本文复制引用
田青青,王书华,安芳..金莲花中荭草苷和牡荆苷对D-半乳糖致衰老小鼠的抗氧化作用[J].神经药理学报,2012,(3):1-6,6.基金项目
张家口市科学技术研究与发展指令计划项目（No.11110015D），河北北方学院自然基金 （）
