神经药理学报Issue(3)：29-36,8.
雌激素神经保护作用研究进展
Progress on the Neuroprotective Effects of Estrogen
摘要
Abstract
In the past few years,there has been a growing interest in the neuroprotective effects of estrogen. An increasing amount of data suggests a neuroprotective role for estrogen, however,the molecular mechanisms whereby estrogen exerts these actions are unclear. In this review,we summarized the data supporting neuroprotection and the potential mechanisms that may contribute to these neuroprotective effects,including classical estrogen receptor activity, activation of the MAPK signaling transduction pathways,attenuation of glutamate receptor activation,antioxidant activity and regulation of mitochondrial function. Estrogen is a multi-faceted hormone modulating many aspects of neuronal function and no single mechanism of action has been elucidated for the neuroprotective effects of estrogens.关键词
雌激素/神经保护/雌激素受体/神经退行性疾病Key words
estrogen/neuroprotective/estrogen receptor(ER)/neurodegenerative diseases分类
医药卫生引用本文复制引用
沈丽霞,张力..雌激素神经保护作用研究进展[J].神经药理学报,2012,(3):29-36,8.基金项目
河北省自然科学基金项目（No.H2012405016），河北北方学院重大项目，河北北方学院创新人才培育项目 （）
