针灸临床杂志Issue(12)：43-45,3.
头穴丛刺结合丰富环境刺激对缺氧缺血性脑损伤新生大鼠突触超微结构和EGFmRNA表达的影响
Influence of Scalp Cluster Acupuncture Combined with Enriched Environmental Stimulation on Synaptic Ultrastructure and EGFmRNA in Newborn Rats with Hypoxic-ischemic Brain Damage
摘要
Abstract
Objective:To investigate effect of scalp cluster acupuncture combined with enriched environmental stimulation on synaptic ultrastructure and EGFmRNA in newborn rats with hypoxic -ischemic brain damage . Methods:HIBD model was established by Rice method .Rats were randomly divided into four groups:A-model group ,B-scalp cluster acupuncture group ,C-enriched environmental stimulation group and D -scalp cluster acupuncture combined with enriched environmental stimulation group .After 7 days,14 days and 21 days,ob-serve the effect of scalp cluster acupuncture combined with enriched environmental stimulation on synaptic ultra -structure and EGFmRNA by using addr .TEM and in situ hybridization ( ISH) .Results:D group was fine of syn-aptic ultrastructure and of the large number of synaptic vesicles and neuron mitochondria swelling significantly reduced.At the same time, in D group at the 14th day and the 21st day,the expression of EGFmRNA was obvi-ously higher than the same period in B group and C group (P<0.01).Conclusion:Scalp cluster acupuncture combined with enriched environmental stimulation could significantly reduce the damage of synaptic ultrastruc -ture by HI and increase the expression of EGFmRNA .关键词
头穴丛刺/丰富环境刺激/缺氧缺血性脑损伤Key words
Cluster needling of scalp point therapy/Enriched environmental stimulation/Hypoxic -ischemic brain damage分类
医药卫生引用本文复制引用
刘波,马晓东,赵宇,邹伟..头穴丛刺结合丰富环境刺激对缺氧缺血性脑损伤新生大鼠突触超微结构和EGFmRNA表达的影响[J].针灸临床杂志,2013,(12):43-45,3.基金项目
黑龙江省博士后资助项目，编号LBH -Z11019；黑龙江中医药管理局项目，编号ZHY12-Z023。 （）
