浙江医学Issue(18)：1659-1663,5.
皮肌炎/多发性肌炎合并肺间质病变的临床特征及预后相关因素
Clinical features of dermatomyositis/polymyositis complicated with interstitial lung disease
周丽 1忻霞菲 1黄华 1覃文 1王庭辉 1赵宝景1
作者信息
摘要
Abstract
Objective To review the clinical characteristics and prognosis of dermatomyositis (DM) and polymyositis (PM) complicated with interstitial lung disease (ILD). Methods The clinical and laboratory data were col ected from 141 patients with DM or PM admitted to Ningbo First Hospital from January 1997 to August 2012.The survival, predicting and prognostic factors of PM/DM patients complicated with ILD were analyzed retrospectively. Results Forty- two out of 141 DM/PM patients were com-plicated with ILD(29.8%).The 1, 5, 10- years survival rates were 76%, 66%and 57%, respectively, with a median survival time of 127.3 months. The presence of clinical ILD and the hyoxemia were the risk factors for DM/PM (OR=2.536, 95%CI 1.205- 5.335, P=0.014 and OR=16.572, 95%CI 3.238- 84.817, P=0.001, respectively). Logistic regression showed that anti- Jo- 1 antibody, me-chanic's hand and hypoproteinemia were positively correlated with ILD in DM/PM.DM/PM complicated by acute or subacute in-terstitial pneumonia progressed rapidly with a high mortality (75%). Treatment with intravenous immuuoglobulin was negatively correlated with mortality in DM/PM- ILD patients (r=- 0.331, P=0.032). Conclusion ILD is a common complication of DM/PM and is also a prognostic factor. The DM/PM patients with anti- Jo- 1 antibody, mechanic's hand and hypoproteinemia tend to compli-cate with ILD. Hyoxemia is a risk factor of poor prognostic in patients with DM/PM- ILD. Early immuuoglobulin treatment might improve the prognosis of DM/PM- ILD.关键词
皮肌炎/多发性肌炎/间质性肺病/预后Key words
Dermatomvositis/Polymyositis/Interstitial lung disease/Prognosis引用本文复制引用
周丽,忻霞菲,黄华,覃文,王庭辉,赵宝景..皮肌炎/多发性肌炎合并肺间质病变的临床特征及预后相关因素[J].浙江医学,2013,(18):1659-1663,5.
