浙江医学Issue(18)：1671-1673,3.
糖尿病患者血浆同型半胱氨酸与围术期心血管事件的相关性分析
Correlation between plasma homocysteine levels and perioperative cardiovascular events in patients with diabetes mellitus
摘要
Abstract
Objective To investigate the correlation between plasma homocysteine (Hcy) levels and perioperative cardio-vascular events (PCEs) in patients with diabetes mel itus undergoing non- cardial surgery. Methods From October 2011 to Oc-tober 2012, 300 diabetic patients underwent elective non- cardiac surgery, including 217 patients with normal plasma Hcy level (Hcy<15.4μmol/L, group N) and 87 with high Hcy level (Hcy≥15.4μmol/L, group H). Various risk factors including gender, age, BMI, ASA classification, fasting blood glucose, HbA1c, blood lipids, Hcy and hs- CRP levels, smoking history, hypertension, pre-operative ECG changes, anesthesia method and operative time were documented in al patients. PCEs were monitored by dy-namic electrocardiography(DCG) for 48h after surgery. Results Perioperative PCEs developed in 59 patients (19.7%). The inci-dences of PCEs were 15.7%and 30.1%in N and H groups, respectively (t=7.937, P=0.005). Compared with N group, hs- CRP, LDL and TG levels and preoperative ECG changes were higher in H group (P<0.05). Conclusion Plasma Hcy levels are closely correlated with the incidence of perioperative cardiovascular events and cardiovascular risk factors in diabetic patients undergo-ing non- cardiac surgery.关键词
糖尿病/高同种半胱氨酸血症/围手术期并发症/心血管疾病Key words
Diabetes mel itus/Hyperhomocysteinemia Intraoperative complications/Cardiovascular diseases引用本文复制引用
吴国荣,郑晋伟,陈骏萍,吴超双,施忠华..糖尿病患者血浆同型半胱氨酸与围术期心血管事件的相关性分析[J].浙江医学,2013,(18):1671-1673,3.基金项目
浙江省宁波市科技局课题 （）
