浙江医学Issue(20)：1791-1794,1801,5.
FasL基因-844T/C单核苷酸多态性与浙江地区食管鳞癌易感性关系的研究
FasL gene -844T/C mutation in relation to susceptibility of esophageal cancer in Zhejiang Province
摘要
Abstract
Objective To explore the relationship between FasL gene- 844T/C single nucleotide polymorphism (SNP)in promoter and susceptibility of esophageal cancer in Zhejiang Province. Methods The clinical data of 248 patients with esophageal squamous cellcarcinoma admitted in Zhejiang Cancer Hospital from January 2008 to October 2011 were col ected and 297 healthy individuals were selected as normal controls. Genomic DNA was extracted from peripheral whole blood. PCR- RFLP technique was carried out to detect FasL- 844T/C SNP. X2 test and logistic regression was carried out for analysis. Results There was significant difference in genotypes of FasL gene promoter - 844 locus between patients and controls (P<0.05). CC genotype significantly reduced the prevalence of esophageal squamous cellcarcinoma risk(adjusted OR =0.425, 95%CI 0.255~0.708, P<0.01). Compared to T al ele, C al ele significantly reduced the prevalence of esophageal squamous cell car-cinoma risk (adjusted OR=0.597, 95%CI 0.460~0.776, P<0.01). Conclusion FasL gene- 844T/C SNP is associated with the occurrence of esophageal squamous cellcarcinoma in population of Zhejiang Province.关键词
FasL基因/单核苷酸多态性/食管癌Key words
FasL gene/SNP/Esophageal cancer引用本文复制引用
王黎芳,赵宏光,李昕如,伊媛琪..FasL基因-844T/C单核苷酸多态性与浙江地区食管鳞癌易感性关系的研究[J].浙江医学,2013,(20):1791-1794,1801,5.基金项目
2013年浙江医学高等专科学校科研基金，2012年浙江省自然科学基金 （）
