浙江医学Issue(20)：1795-1798,1801,5.
血清抗髓鞘少突胶质细胞糖蛋白抗体对多发性硬化的诊断意义
Serum levels of anti-myelin oligodendrocyte glycoprotein antibody in diagnosis of multiple sclerosis
摘要
Abstract
Objective To assess serum levels of anti- myelin oligodendrocyte glycoprotein (MOG) antibody in diagnosis of multiple sclerosis(MS). Methods The serum levels of anti- MOG antibody were detected with radioimmunoassay(RIA) in 23 pa-tients with MS, 57 patients with clinical y isolated syndrome(CIS), 41 patients with other inflammatory neurological diseases(OIND) and 37 patients with other non- inflammatory neurological diseases (ONND). The burden of disease (BOD) in patients with central nervous system demyelinating diseases was assessed by T2- weighted MRI and the relationship between anti- MOG antibody level and BOD was analyzed. The sensitivity and specificity of serum anti- MOG antibody, CSF IgG index, IgG 24- h synthesis rate for diagnosis of MS were evaluated with receiver operating characteristic curve (ROC). Results The serum levels of anti- MOG antibody and positive rate in MS group were significantly higher than those in CIS group, OIND group and ONND group (P<0.01). The serum levels and positive rate of anti- MOG antibody in MS patients were correlated with disease activity (P<0.05). The serum levels of anti- MOG antibodies were correlated with BOD in patients with demyelinating disease (MS and CIS group)(P<0.01). In ROC curve the area under the curve (AUC) of anti- MOG antibody was larger than that of CSF IgG index and 24- h IgG synthesis rate. Conclusion The serum levels of anti MOG antibody can be used as a reliable biomarker for diagnosis of MS.关键词
髓鞘少突胶质细胞糖蛋白自身抗体/多发性硬化/放射免疫分析/受试者工作特征曲线/病灶负荷Key words
Anti- myelin oligodendrocyte glycoprotein antibody (anti- MOG antibody)/Multiple Sclerosis (MS)/Ra-dioimmunoassay(RIA)/Receiver operating characteristic curve (ROC curve)/Burden of disease(BOD)引用本文复制引用
厉向,夏君慧,张旭..血清抗髓鞘少突胶质细胞糖蛋白抗体对多发性硬化的诊断意义[J].浙江医学,2013,(20):1795-1798,1801,5.基金项目
温州市科技局基金资助项目 （）
