浙江医学Issue(20)：1813-1815,3.
原因不明性复发性流产淋巴细胞免疫治疗的剂量及疗效研究
Efficacy of immunotherapy with different doses for unexplained recurrent spontaneous abortion
摘要
Abstract
Objective To assess the efficacy of lymphocyte therapy with different doses for unexplained recurrent spon-taneous abortion (URSA). Methods One hundred and sixty five women with URSA received lymphocyte therapy with different doses. The outcomes of pregnancy were documented and the percentage of CD4+CD25+Tr in peripheral blood was measured by flow cytometry before and after lymphocyte therapy. Results Among 165 patients re- pregnancy was obtained in 121 cases, in whom 87 cases were successful y delivered, 14 cases had early abortion and 20 cases were stil under pregnancy with a success rate of 88.5%. Thirty seven cases with low dose treatment all obtained re- pregnancy, including 29 cases of successful delivery and 8 cases of early abortion with a success rate of 72.4%, which was significantly lower than that of high dose group (92.3%, P<0.05). After treatment the level of CD4 +CD25bright T was significantly (P<0.05) higher than before treatment. The CD4 +CD25 +Tr and CD4 +CD25bright T levels in patients with successful pregnancy were significantly higher than those with failed pregnancy (P<0.05). Conclusion Lymphocyte therapy is effective for URSA women, particularly with high dose lymphocytes, which is associ-ated with increased CD4 +CD25bright T and CD4 +CD25bright Tr levels in peripheral blood.关键词
原因不明性复发性流产/CD4+CD25+T细胞/淋巴细胞免疫治疗Key words
URSA/CD4+CD25+Tr/Lymphocyte therapy引用本文复制引用
王海燕,吴晓云,李晓荣,魏丽娜,邱惠麒,朱国战,周媛萍..原因不明性复发性流产淋巴细胞免疫治疗的剂量及疗效研究[J].浙江医学,2013,(20):1813-1815,3.基金项目
湖州市科技计划项目 （）
