浙江医学Issue(20)：1823-1826,4.
低剂量吉西他滨持续静脉滴注在晚期非小细胞肺癌维持治疗中的应用
Prolonged infusion of low-dose gemcitabine in maintenance treatment for advanced non-small cell lung cancer：a phase Ⅱ trial
陈俊 1陶庆松 1庞林荣 1李晖 1徐彩虹 1黄佳 1郑宏瑜 1杨成1
作者信息
- 1. 315040 宁波大学附属鄞州人民医院肿瘤放化疗中心
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of prolonged infusion of low- dose gemcitabine in maintenance treatment for advanced non- smal celllung cancer (NSCLC) after first line regimen. Methods Sixty six patients with stageⅢB/Ⅳ NSCLC admitted from March 2008 to October 2009 were enrolled. The patients received gemcitabine 1000 mg/m2 (d1 and d8)plus cisplatin 25 mg/m2 (d1, d2 and d3) every 21 d. Thirty six patients achieving objective response or stable disease fol ow-ing initial gemcitabine plus cisplatin regime were randomized to receive maintenance gemcitabine (continuous injection for 6h with a dose of 250 mg/m2 on d1 and d8, every 21d)plus best supportive care (maintenance arm), or best supportive care only (control arm). Results The time to progress (TTP) throughout the study period was 6.2 and 4.8 months for maintenance and control arms, respectively (P=0.039). Median overal survival (OS) was 13.1 months for maintenance and 10.8 months for control arms(P=0.667). The toxicity profile was mild,with neutropenia,thrombocytopenia,anemia,nausea and vomit being most common toxicities. Conclusion Maintenance treatment with low- dose gemcitabine,fol owing first line regime is feasible and it produces significantly longer TTP compare to best supportive care alone.关键词
非小细胞肺癌/维持化疗/低剂量/吉西他滨Key words
NSCLC/maintenance chemotherapy/Low- dose/Gemcitabine引用本文复制引用
陈俊,陶庆松,庞林荣,李晖,徐彩虹,黄佳,郑宏瑜,杨成..低剂量吉西他滨持续静脉滴注在晚期非小细胞肺癌维持治疗中的应用[J].浙江医学,2013,(20):1823-1826,4.
