浙江医学Issue(21)：1886-1889,1899,5.
骨保护素在绝经妇女糖尿病骨质疏松中的作用
Effect of osteoprotegerin in postmenopausal women with diabetic osteoporosis
裘静英 1李成江 2董志春 1沈建江3
作者信息
- 1. 312400 嵊州市人民医院内分泌科
- 2. 浙江大学医学院附属第一医院内分泌代谢科
- 3. 312400 嵊州市人民医院检验科
- 折叠
摘要
Abstract
Objective To investigate the difference of serum osteoprotegerin (OPG) levels between primary osteoporosis and diabetic osteoporosis. Methods One hundred twenty natural postmenopausal women were enrol ed in the study, including 30 diabetic patients with osteoporosis, 30 diabetic patients without osteoporosis, 30 non- diabetic patients with osteoporosis and 30 non- diabetic women without osteoporosis. Serum OPG levels were measured by enzyme- linked immunosorbent assay (ELISA). Results OPG levels in non- diabetic patients with osteoporosis were higher than those in non- diabetic women without osteoporosis (P<0.01). OPG levels in diabetic patients with osteoporosis were higher than those in diabetic patients without os-teoporosis(P<0.05). OPG levels in diabetic patients with osteoporosis were higher than those in non- diabetic patients with osteo-porosis(P<0.05). OPG levels in diabetic patients without osteoporosis were higher than those in non- diabetic women without os-teoporosis (P<0.01). OPG levels were positively correlated with HbA1c and FPG levels (r=0.89 and 0.67, respectively;P<0.05). Conclusion Diabetic patients with osteoporosis have higher levels of serum OPG, indicating that OPG may be associated with di-abetic osteoporosis in postmenopausal women. The increased HbA1c levels in diabetic patients with osteoporosis indicate that the control of blood glucose may be important for prevention of diabetic osteoporosis.关键词
骨保护素/骨质疏松/2型糖尿病/绝经妇女Key words
Osteoprotegerin/Osteoporosis/Type 2 diabetes/Postmenopausal women引用本文复制引用
裘静英,李成江,董志春,沈建江..骨保护素在绝经妇女糖尿病骨质疏松中的作用[J].浙江医学,2013,(21):1886-1889,1899,5.
