浙江医学Issue(22)：1982-1984,1988,4.
川芎嗪抑制大鼠颈动脉球囊损伤后再狭窄的在体研究
Tetramethylpyrazine prevents balloon-injured carotid artery from restenosis in rats
摘要
Abstract
Objective To investigate the preventive effect of tetramethylpyrazine (TMP) on bal oon- injured rat carotid artery from restenosis. Methods Bal oon- injured carotid artery model was established in SD rats. SD rats were divided into 3 groups:sham operation group(n=8);model group(n=8) and TMP group(n=8). In TMP group, rats were pretreated with caudal vein injection of TMP (10mg/kg·d) for 1 week, and the same dose of TMP was continued for 6 weeks after bal oon angioplasty. Injured segments of carotid artery were harvested at 6th week and embedded in paraffin wax to assess the size of intimal lesions by HE staining. Proteins expressions of Wnt4, Dvl- 1,β- catenin and Cyclin- D1 were detected by Western blotting method. Results Six weeks after bal oon injured, the intimal of injured artery became thickening. The ratio of intima/tunica media thickness and col-lagen volume in intima increased significantly compared to those of sham operation group (P<0.05). Compared to model group, the ratio of intima/tunica media thickness in TMP group reduced significantly (P<0.05). The expressions of Wnt4, Dvl- 1,β- catenin and Cyclin- D1 proteins in model group increased significantly in comparison with sham operation group, while de-creased in comparison with TMP group. Conclusion TMP can inhibit restenosis of bal oon- injured carotid artery possibly through down- regulation of wnt signal pathway.关键词
川芎嗪/Wnt信号通路/血管再狭窄/血管内膜Key words
Tetramethylpyrazine/Wnt signal pathway/Restenosis/Intima引用本文复制引用
华军益,何煜舟,蒋旭宏,叶武,潘智敏..川芎嗪抑制大鼠颈动脉球囊损伤后再狭窄的在体研究[J].浙江医学,2013,(22):1982-1984,1988,4.基金项目
浙江省医药卫生科技计划项目（2010KWA155）；浙江省中医药科学研究基金项目 （）
