浙江医学Issue(23)：2047-2049,2079,4.
自噬相关蛋白Beclin1、MAPLC3在胃癌中的表达及临床意义
Expression of Beclin1 and MAPLC3 in the tissue of gastric cancer and its significance
杨勇明 1崔健 1丁丽君 1王建江 1阮华娟 2方亚平3
作者信息
- 1. 311300 临安市人民医院胃肠外科
- 2. 311300 临安市人民医院病理科
- 3. 311300 临安市人民医院消化内科
- 折叠
摘要
Abstract
Objective To investigate the expression of Beclin1 and MAPLC3 in gastric cancer and clinical significance. Methods Immunohistochemical assay was performed to detect the expression of Beclin1 and MAPLC3 in fifty- nine gastric carci-noma tissues and their adjacent noncancerous specimens. Results (1) The expression of Beclin1 and MAPLC3 was both de-creased in carcinoma tissues(24/59, 40.7%and 26/59, 44.1%), which were significantly lower than those in noncancerous tissues (P<0.05).(2)The expression of both Beclin1 and MAPLC3 was correlated with depth of invasion, lymph node metastasis and TNM classification (P<0.05).(3) There was positive correlation between the expression of Beclin1 and MAPLC3 (r=0.425, P<0.05). Conclusion The expression of Beclin1 and MAPLC3 both reduced in gastric carcinoma tissues, and the downregulation of Beclin1 is significantly associated with MAPLC3. The co- downregulation of Beclin1 and MAPLC3 may play an important role in lymphatic spread of gastric carcinoma.关键词
胃肿瘤/Beclin1基因/MAPLC3基因Key words
Gastric cancer/Beclin1/MAPLC3引用本文复制引用
杨勇明,崔健,丁丽君,王建江,阮华娟,方亚平..自噬相关蛋白Beclin1、MAPLC3在胃癌中的表达及临床意义[J].浙江医学,2013,(23):2047-2049,2079,4.
