浙江医学Issue(23)：2065-2067,2102,4.
类风湿关节炎患者血清中抗环瓜氨酸肽抗体不同亚型的临床意义
Clinical significance of the different subtypes of anti-cyclic citrullinated peptide antibodies in patient with rheumatoid arthritis
摘要
Abstract
Objective To investigate the subtypes of the anti- cyclic citrul inated peptide (CCP) antibodies in patients with rheumatoid arthritis(RA) and its clinical significance. Methods The subtypes of anti- CCP antibodies including IgA, IgG and IgM were detected by enzyme- linked immunosorbent assay (ELISA) in patients serum samples of 135 patients with RA, 53 patients with non- RA connective tissue diseases (CTD) and 45 healthy controls. Results IgA, IgG and IgM anti- CCP antibodies were present in 57.8%、73.3% and 30.4% of RA patients, and their diagnostic specificity was 96.9%,96.9% and 95.9%, respectively. The positive rate of IgA, IgG and IgM anti- CCP antibodies were significant higher than those in non- RA CTD and healthy controls (P<0.05). The positive rate of IgA, IgG and IgM anti- CCP antibodies were more frequently in RA patients with positive rheuma-toid factor (RF)- IgM than that in negative RF- IgM RA patients (P<0.05). The positive rate of IgA, IgG anti- CCP antibodies in RA patients with disease duration≥24months and 6~24months groups were significant higher than those in≤6 group. The positive rate of IgM anti- CCP antibodies in≥24months group was significant lower than in≤6 group. There was no statistical y signifi-cant difference (P>0.05) between 6~24months group and≥24months group or≤6 group. Conclusion The subtypes of an-ti- CCP antibodies are common in patients with RA. IgA and IgM anti- CCP antibodies are similarly specific for RA as IgG an-ti- CCP antibodies.关键词
类风湿关节炎/抗环瓜氨酸肽抗体/亚型Key words
Rheumatoid arthritis/Anti- cyclic citrul inated peptide antibodies/Subtypes引用本文复制引用
杨清萍..类风湿关节炎患者血清中抗环瓜氨酸肽抗体不同亚型的临床意义[J].浙江医学,2013,(23):2065-2067,2102,4.
