浙江医学Issue(24)：2166-2169,4.
BAG-1与脑膜瘤瘤周水肿及术后复发的关系
Correlation of BAG-1 expression with peritumoral edema and postoperative recurrence in patients with meningioma
摘要
Abstract
Objective To investigate the relationship between BAG- 1 expression with postoperative recurrent and peritu-moral edema in patients with meningioma. Methods The expression of BAG- 1 was detected with immunohistochemical SP method in brain tissue specimens from 158 patients with meningioma. The relationship of BAG- 1 expression in meningioma with peritumoral edema and postoperative recurrence was analyzed. Results There was significant difference in BAG- 1 expression degree between grade I meningioma(including epithelial, fibril ar, mixed, microcystic and psammomatous subtypes) and grade II (atypical, chordoid subtypes) or grade III (papil ary, anaplastic subtypes) (P<0.05 or 0.01). High degree BAG- 1 expression in postoperative recurrence cases and no- recurrence cases were 12.50%(3/24) and 76.12%(102/134), respectively(P<0.05). There was no significant difference in expression degree of BAG- 1 between peritumoral edema grade 0 and grade 1 or grade 2 to grade 3 (al P>0.05). But the expression degree of BAG- 1 between peritumoral edema grade 0 or 1 and the grade 2 or 3, the difference had statistical significance (al P<0.05). Conclusion The expressions of BAG- 1 are negatively correlated with peritu-moral edema and postoperative recurrent in meningrioma.关键词
脑膜瘤/BAG-1/凋亡/瘤周水肿/复发Key words
Meningioma/BAG- 1/Apoptosis/Peritumoral edema/Postoperative recurrence引用本文复制引用
周开宇,金杭煌,周婷,罗永康,陈茜..BAG-1与脑膜瘤瘤周水肿及术后复发的关系[J].浙江医学,2013,(24):2166-2169,4.基金项目
浙江省医药卫生科技计划资助项目（2012KYB243）；台州市科技局资助项目 （）
