浙江医学Issue(3)：182-183,186,3.
白芍总苷对内毒素性心肌炎大鼠心肌组织炎症因子的影响
Effect of total glucosides of paeony on expression of inflammatory factors in myocardial tissue of rats with myocarditis induced by endotoxin
摘要
Abstract
Objective To investigate whether total glucosides of paeony (TGP) could inhibit expression of inflammatory factors in myocardial tissue of rats with myocarditis. Methods Myocarditis was induced by injection of endotoxin LPS through the tail vein in rats; then low, middle or high doses of TGP were administered by gastric perfusion respectively. Histopathological changes were examined by HE staining;the expression of TNF- α, IL- 1βand NF- κB in myocardial tissue was detected by im-munohistochemistry. Results Histopathology demonstrated marked inflammation in cardiac tissue with infiltration of inflammatory cells. TGP with middle and high dose al eviated inflammation in cardiac tissue. Expression of TNF- α, IL- 1βand NF- κB was up- graded in rats with myocarditis, which was attenuated in middle and high dose- TGP groups(P<0.01). Conclusion TGP with middle or high dose can effectively inhibit inflammation in cardiac tissue of rats with endotoxin- induced myocarditis.关键词
白芍总苷/内毒素血症/心肌炎/TNF- α/IL- 1β/NF- κBKey words
Total glucosides of paeony/Endotoxemia/Myocarditis/TNF- α/IL- 1β/NF- κB引用本文复制引用
蒋旭宏,华军益,潘智敏,何煜舟,叶武,毛威,阮善明,丁黎敏,黄兆铨..白芍总苷对内毒素性心肌炎大鼠心肌组织炎症因子的影响[J].浙江医学,2014,(3):182-183,186,3.基金项目
浙江省中医药科学研究基金项目（2011ZB047）；浙江省中医药科学研究基金项目 （）
