浙江医学Issue(3)：184-186,3.
MiRNA-24在良、恶性胸水鉴别诊断中的应用价值研究
MicroRNA-24 is expressed at high level in malignant pleural effusion
摘要
Abstract
Objective To investigate the expression levels of microRNAs in malignant and benign pleural effusion. Meth-ods Pleural effusion samples were col ected from 18 cases of lung cancer and 10 cased of benign diseases. The expression levels of let- 7b, miRNA- 24, miRNA- 27b, miRNA- 30d and miRNA- 128a in the pleural effusion were detected with stem loop primer FQ RT- PCR method. Results The expression of miRNA- 24 in malignant pleural effusion was higher than that in benign pleural effusion (P=0.032);however there were no significant difference in expression of Let- 7b, miRNA- 27b, miRNA- 30d and miRNA- 128a between malignant and benign pleural effusion (P=0.076, 0.320, 0.076 and 0.372, respectively). Conclusion miR-NA- 24 is expressed at higher level in malignant pleural effusion, indicating that miRNA- 24 may be used to differentiate malignant pleural effusion from benign one.关键词
胸腔积液/microRNA/诊断Key words
Pleural effusion/MicroRNA/Diagnosis引用本文复制引用
张斌杰,乐涵波,张永奎,刘晓光,周吉航,竺王玉,陈志军..MiRNA-24在良、恶性胸水鉴别诊断中的应用价值研究[J].浙江医学,2014,(3):184-186,3.基金项目
浙江省卫生厅基金资助项目（2011KYB165）；舟山市科技局重大项目 （）
