浙江医学Issue(3)：198-200,3.
食管鳞癌中MEKK3和NF-κB的表达及其临床意义
Expression of MEKK3, NF-κB proteins in esophageal squamous cell carcinoma and their clinical significance
殷宪刚 1葛荣 1周新成 1陈金平 1夏朝霞1
作者信息
- 1. 315031 宁波市临床病理诊断中心诊断部
- 折叠
摘要
Abstract
Objective To study the expression of mitogen- activated protein kinase/extracellular signal- regulated kinase kinase kinase 3(MEKK3) and nuclear factor kappa B(NF- κB) proteins in esophageal squamous cellcarcinoma(ESCC) and their clinical significance. Methods The expression of MEKK3 and NF- κB proteins in 76 cases of ESCC, 35 cases of adjacent atyp-ical hyperplasia tissues and 20 cases of normal tissue were detected by immunohistochemistry EnVision method. Results The positive rates of MEKK3 protein in ESCC tissue were significantly higher than those of atypical hyperplasia tissue and normal tis-sue(P<0.05). The positive rates of NF- κB protein were increased gradual y in ESCC tissue, atypical hyperplasia tissue and nor-mal tissue. In ESCC tissue, the positive expression of MEKK3 and NF- κB proteins was both correlated with the clinical stage, in-filtration depth and lymph node metastasis(al P<0.05), but not correlated with age, sex, or degree of differentiation(al P>0.05). Expression of MEKK3 protein was positively associated with expression of NF- κB (r=0.308, P<0.05). Conclusion The expres-sion of MEKK3 and NF- κB proteins can be used as a indicator for the diagnosis of ESCC and the prognosis of patients.关键词
有丝分裂原活化蛋白激酶激酶激酶3/核转录因子/食管鳞癌Key words
MEKK3 NF- κB/Esophageal squamous/cellcarcinoma引用本文复制引用
殷宪刚,葛荣,周新成,陈金平,夏朝霞..食管鳞癌中MEKK3和NF-κB的表达及其临床意义[J].浙江医学,2014,(3):198-200,3.
