摘要
Abstract
Objective To evaluate serum tumor specific growth factor (TSGF) and CA125 levels in diagnosis of en-dometriosis (EMs). Methods Serum TSGF and CA125 levels were determined by chemiluminescence microparticle immunoas-say(CMIA) and biochemical photoelectric colormetry (BPC) respectively in 110 patients with EMs and 127 healthy subjects. Re-sults The preoperative serum TSGF and CA125 levels in patients with EMs were significantly higher than those in controls (P<0.01). One month after operation, serum TSGF and CA125 levels were decreased significantly (P<0.01), whereas they were stil higher than those in controls(P<0.01). Three months after operation, serum TSGF and CA125 levels dropped as in controls (P>0.05). One year after treatment, TSGF levels in 5 relapse patients were higher than those in controls (P<0.01), while there was no difference in CA125 levels (P>0.05). Moreover, serum TSGF levels in stage III, IV of EMs were significantly higher than those in controls (P<0.01), and TSGF level in stage IV was higher than that in stage III (P<0.05). Serum CA125 levels in stage III, IV were higher than those in controls (P<0.01), but there was no difference between stages III and IV (P>0.05). Taking 64U/ml of TSGF, 35U/ml of CA125 cut- off values, the sensitivity for diagnosis of EMs was 80.9%, specificity was 85.0%, and the diagnostic accor-dance rate was 83.1%. Conclusion The sensitivity and specificity of serum TSGF combined with CA125 are satisfactory in diag-nosis of EMs. Serum TSGF level is positively correlated with r- AFS stages of EMs, and can be used for early detection of relapse in patients with EMs.关键词
子宫内膜异位症/肿瘤特异性生长因子/糖类抗原125Key words
Endometriosis/TSGF(tumor specific growth factor)/CA125
