肿瘤药学Issue(5)：344-347,4.DOI:10.3969/j.issn.2095-1264.2013.085
罗勒多糖抗肿瘤转移作用的机制研究
A Study on the Anti-tumor Metastasis Mechanism of Basil Polysaccharide
摘要
Abstract
Objective To explore the possible mechanisms of basil polysaccharide in inhibiting tumor metastasis. Methods Assayed the metastasis of tumor cell ability by Metrigel in vitro. Established different pathways model of tumor metastasis in vivo, and observed the influence of basil polysaccharide on tumor metastasis behavior. Tested the effect of basil polysaccharide on the recovering of cell communication by Lucifer Yellow scrape loading and dye transfer (SLDT) technique. Results The number of PG cells that went through artificial basement membrane were significantly reduced after treatment with different concentra-tions of basil polysaccharide for 48h. Basil polysaccharide had significantly inhibiting effect on melanoma B16-F10 artificial lung spontaneous metastatic behavior;and played a certain role in cell communication recovery. Conclusion The inhibition of tumor cell migration and recovery of tumor cell communication function may be involved in the anti-tumor metastasis effect of Basil polysaccharide.关键词
罗勒多糖/肿瘤转移/机制研究Key words
Basil polysaccharide/Tumor metastasis/Mechanism分类
医药卫生引用本文复制引用
赵庆华,赵豫..罗勒多糖抗肿瘤转移作用的机制研究[J].肿瘤药学,2013,(5):344-347,4.基金项目
济南军区后勤科研计划项目(CJN121078)。 （CJN121078）
