肿瘤药学Issue(5)：365-367,381,4.DOI:10.3969/j.issn.2095-1264.2013.090
GP和GEM+NDP方案治疗复发转移性乳腺癌的临床疗效分析
Analysis of the Clinical Efficacy of GP and GEM+NDP Regimen in the Treatment of Recurrent and Metastatic Breast Cancer
杨镇休 1宋向群2
作者信息
- 1. 广西钦州市第一人民医院肿瘤内2科，广西 钦州，530099
- 2. 广西壮族自治区肿瘤医院化疗2科，广西 南宁，530000
- 折叠
摘要
Abstract
Objective To analyze the clinical efficacy and toxicities of gemcitabine combined with cisplatin and gemcitabine combined with Nedaplatin (NDP) on recurrent and metastatic breast cancer (MBC). Methods Fifty-two MBC patients were di-vided into gemcitabline combined with cisplatin (GP) Group (n=29) and gemcitabline combined with nedaplatin (GEM+NDP) Group (n=23) by using the principle of random assigning. The two treatments took 21 days as a cycle. The clinical efficacy and the toxicities were evaluated after two cycles and four cycles. Results After two cycles, the overall response rate (ORR) was 48.28%and 60.87%respectively in GP Group and GEM+NDP Group, and there was no significant difference between them (P>0.05). Except the PD patients, the others continued to get chemotherapy. After four cycles, the ORR was 31.58%and 50.00%respectively in GP Group and GEM+NDP Group, and there was still no significant difference between them (P>0.05). There were no significant differences between the two groups in the incidence of third degree leucopenia, Third degree throm-bocytopenia and anemia. The incidence of gastrointestinal reaction in GEM+NDP Group (13.0%) was obviously lower than that of GP Group (69.0%), with significant difference (P<0.05). There was one case (3.4%)of First degree impaired renal function and five cases (17.2%) of Second degree impaired renal function in GP Group, while in GEM+NDP Group there was only one case (4.3%) of First degree impaired renal function. There were significant differences between them (P<0.05). Conclusion GP regimen and GEM+NDP regimen had similar efficacy in the treatment of anthracycline or taxane-resistant recurrent and meta-static breast cancer, and the toxicities can be tolerated.关键词
复发转移性乳腺癌/吉西他滨/奈达铂/顺铂/临床疗效Key words
Recurrent and Metastatic breast cancer/Gemcitabine/Nedaplatin/Cisplatin/Clinical efficacy分类
医药卫生引用本文复制引用
杨镇休,宋向群..GP和GEM+NDP方案治疗复发转移性乳腺癌的临床疗效分析[J].肿瘤药学,2013,(5):365-367,381,4.
