肿瘤药学Issue(5)：378-381,4.DOI:10.3969/j.issn.2095-1264.2013.094
替吉奥单药治疗老年晚期胃癌的临床疗效分析
Clinical Study on the Effect of Monotherapy of Tegafer Gimeracil Oteracil Porassium Capsules on Elderly Advanced Gastric Cancer
王青兵 1王雁军 1张勇 1黄天臣 1肖建安1
作者信息
- 1. 安阳肿瘤医院外四科，河南 安阳，455000
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and toxicity of Tegafer Gimeracil Oteracil Porassium (S-1) in the treat-ment of elderly patients with advanced gastric cancer. Methods 62 cases of elderly advanced gastric cancer were randomly divided into two groups:the S-1 group (n=36) and the control group (n=26). The S-1 group was only treated with S-1 twice daily, and the control group was treated by FOLFOX4. The effect and toxicities in the two groups were analyzed after three cycles of chemotherapy. Results No significant difference was observed in response rate (25.0%vs. 26.9%) and one-year survival rate (47.20%vs. 53.8%) between the two groups. But the improvement rate of quality of life was significantly higher in S-1 group than in the control group, and the adverse reaction rate was lower in S-1 group than in control group. Peripheral neurotoxicity was only observed in the control group. Conclusion The S-1 had an equivalent clinical efficacy to FOLFOX4 regimen in the treatment of elderly patients with advanced gastric cancer, but it was safer than FOLFOX4 regimen.关键词
老年晚期胃癌/替吉奥/化疗/FOLFOX4方案Key words
Elderly Advanced Gastric Cancer/S-1/Chemotherapy/FOLFOX4 regimen分类
医药卫生引用本文复制引用
王青兵,王雁军,张勇,黄天臣,肖建安..替吉奥单药治疗老年晚期胃癌的临床疗效分析[J].肿瘤药学,2013,(5):378-381,4.
